Latino-Targeted Misinformation and the Power of Factual Corrections

Do individual, interpersonal, or institutional factors condition the effects of misinformation on beliefs? Can interventions such as fact checks stem the tide of the "infodemic” within marginalized communities? We explore the sudden flood of misinformation and disinformation targeting Latinos during the 2020 election and global COVID-19 pandemic to answer these questions. In a preregistered experiment, we find that exposure to misinformation can decrease factual accuracy, and neither trust in nor consumption of media, including ethnic media, serves as a buffer against these misinformation effects. However, fact checks eliminate the effects of misinformation on false beliefs without "backfiring” and reducing accuracy. Fact checks improve factual accuracy among subgroups varying in levels of political knowledge, trust, and acculturation. These findings provide crucial support for recent investments into fact checking by Latino-oriented media outlets and address gaps within the literature over whether such interventions are also effective within marginalized groups.

Correcting COVID-19 vaccine misinformation in 10 countries

What can be done to reduce misperceptions about COVID-19 vaccines? We present results from experiments conducted simultaneously on YouGov samples in 10 countries (N = 10 600), which reveal that factual corrections consistently reduce false beliefs about vaccines. With results from these 10 countries, we find that exposure to corrections increases belief accuracy by 0.16 on a 4-point scale, while exposure to misinformation decreases belief accuracy by 0.09 on the same scale. We are unable to find evidence that either misinformation or factual corrections affect intent to vaccinate or vaccine attitudes. Our findings on effect duration are less conclusive;when we recontacted participants two weeks later, we observed 39% of the initial accuracy increase, yet this result narrowly misses conventional thresholds of statistical significance (p = 0.06). Taken together, our results illustrate both the possibilities and limitations of factual corrections. Evidence from 10 highly diverse populations shows that exposure to factual information reduces belief in falsehoods about vaccines, but has minimal influence on subsequent behaviours and attitudes.

Factual Corrections Eliminate False Beliefs About COVID-19 Vaccines

The spread of misinformation about COVID-19 vaccines threatens to prolong the pandemic, with prior evidence indicating that exposure to misinformation has negative effects on intent to be vaccinated. We describe results from randomized experiments in the United States (n = 5,075) that allow us to measure the effects of factual corrections on false beliefs about the vaccine and vaccination intent. Our evidence makes clear that corrections eliminate the effects of misinformation on beliefs about the vaccine, but that neither misinformation nor corrections affect vaccination intention. These effects are robust to formatting changes in the presentation of the corrections. Indeed, corrections without any formatting modifications whatsoever prove effective at reducing false beliefs, with formatting variations playing a very minor role. Despite the politicization of the pandemic, misperceptions about COVID-19 vaccines can be consistently rebutted across party lines.

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasma proteome data using published scRNA-seq datasets reveals contributions from circulating immune and tissue cells. Sixteen percent of patients display reduced inflammation yet comparably poor outcomes. Comparison of patients who died to severely ill survivors identifies dynamic immune-cell-derived and tissue-associated proteins associated with survival, including exocrine pancreatic proteases. Using derived tissue-specific and cell-type-specific intracellular death signatures, cellular angiotensin-converting enzyme 2 (ACE2) expression, and our data, we infer whether organ damage resulted from direct or indirect effects of infection. We propose a model in which interactions among myeloid, epithelial, and T cells drive tissue damage. These datasets provide important insights and a rich resource for analysis of mechanisms of severe COVID-19 disease.

The global effectiveness of fact-checking: Evidence from simultaneous experiments in Argentina, Nigeria, South Africa, and the United Kingdom.

The spread of misinformation is a global phenomenon, with implications for elections, state-sanctioned violence, and health outcomes. Yet, even though scholars have investigated the capacity of fact-checking to reduce belief in misinformation, little evidence exists on the global effectiveness of this approach. We describe fact-checking experiments conducted simultaneously in Argentina, Nigeria, South Africa, and the United Kingdom, in which we studied whether fact-checking can durably reduce belief in misinformation. In total, we evaluated 22 fact-checks, including two that were tested in all four countries. Fact-checking reduced belief in misinformation, with most effects still apparent more than 2 wk later. A meta-analytic procedure indicates that fact-checks reduced belief in misinformation by at least 0.59 points on a 5-point scale. Exposure to misinformation, however, only increased false beliefs by less than 0.07 points on the same scale. Across continents, fact-checks reduce belief in misinformation, often durably so.

Team Approach: Virtual Care in the Management of Orthopaedic Patients.

¼: Telemedicine and remote care administered through technology are among the fastest growing sectors in health care. The utilization and implementation of virtual-care technologies have further been accelerated with the recent COVID-19 pandemic. ¼: Remote, technology-based patient care is not a "one-size-fits-all" solution for all medical and surgical conditions, as each condition presents unique hurdles, and no true consensus exists regarding the efficacy of telemedicine across surgical fields. ¼: When implementing virtual care in orthopaedics, as with standard in-person care, it is important to have a well-defined team structure with a deliberate team selection process. As always, a team with a shared vision for the care they provide as well as a supportive and incentivized environment are integral for the success of the virtual-care mechanism. ¼: Future studies should assess the impact of primarily virtual, integrated, and multidisciplinary team-based approaches and systems of care on patient outcomes, health-care expenditure, and patient satisfaction in the orthopaedic population.

Metabolic health and lifestyle medicine should be a cornerstone of future pandemic preparedness

Abstract The recent impact of SARS-CoV-2 and coronavirus disease 2019 (COVID-19) has shown major differences in infrastructure and approach across healthcare systems worldwide. One thing we can already be certain of is that governments and policy makers worldwide will place a greater focus on pandemic preparedness in the future. However, as well as ensuring that robust pipelines for rapid test, highly effective treatment or vaccine, and personal protective equipment (PPE) production are in place, we must address underlying resilience and susceptibility of our populations to infectious disease. Although the true spread and case fatality rate of SARS-CoV-2 may not be known for several months or even years, what is becoming increasingly clear is the significant degree to which underlying conditions associated with suboptimal metabolic health appear to be associated with poor outcomes in those with COVID-19. Considering the nature of these underlying conditions, such as obesity and hypertension, lifestyle-based approaches are likely to be one of our best tools in order to address ongoing and future disease burden during pandemics.